Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117029
Country	China

Category	Andrology
Manuscript Type	Editorial
Article Title	Deconstructing the androgen function in active perianal infection: Investigating inflammation-driven hypogonadal state
Manuscript Source	Invited Manuscript
All Author List	Ze-Jun Zhang, Ji-Xue Wang, Chun-Xi Wang and Liang He
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation Project of Jilin Province YDZJ202301ZYTS100
Corresponding Author	Liang He, MD, PhD, Department of Urology, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lianghe9278@jlu.edu.cn
Key Words	Testosterone; Perianal diseases; Systemic inflammatory stress; Metabolic disorders; Obesity
Core Tip	Acute perianal abscess is not only a localized infection but triggers a systemic inflammatory response that rapidly suppresses testosterone production. This inflammation-driven hypogonadal state challenges the traditional assumption that high androgen levels contribute to disease initiation and highlights the importance of integrating endocrine and metabolic factors into the understanding and management of perianal infections.
Citation	Zhang ZJ, Wang JX, Wang CX, He L. Deconstructing the androgen function in active perianal infection: Investigating inflammation-driven hypogonadal state. World J Gastrointest Surg 2026; In press

Received	2025-11-27 01:00
Peer-Review Started	2025-11-27 07:29
First Decision by Editorial Office Director	2025-12-25 07:34
Return for Revision	2025-12-25 07:34
Revised	2026-01-03 15:24
Publication Fee Transferred
Second Decision by Editor	2026-01-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 06:06
Articles in Press	2026-01-14 06:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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