Publication Name	World Journal of Gastroenterology
Manuscript ID	117033
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Unlinking lymphocyte counts from disease severity in patients with acute-on-chronic liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Bo-Ya Xie, Ya-Rong Ma and Zhi-Gang Ren
Funding Agency and Grant Number	Funding Agency Grant Number Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project No. 2025ZD01906305 Natural Science Foundation Key Project of Henan Province No. 232300421124 Henan Zhongyuan Medical Science and Technology Innovation and Development Foundation No. ZYYC202301ZD
Corresponding Author	Zhi-Gang Ren, MD, PhD, Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Jianshe East Road, Zhengzhou 450052, Henan Province, China. fccrenzg@zzu.edu.cn
Key Words	Peripheral blood lymphocyte subset; Acute-on-chronic liver failure; Liver transplantation; Dynamic monitoring; Functional status
Core Tip	Commenting on the study by Peng et al, we offer insights into the finding that absolute counts of peripheral blood lymphocyte subsets are not significantly correlated with the etiology of acute-on-chronic liver failure, severity scores across multiple diseases, or long-term outcomes after liver transplantation. We believe that greater emphasis should be placed on monitoring the functional status of peripheral blood lymphocytes to better understand disease progression.
Citation	Xie BY, Ma YR, Ren ZG. Unlinking lymphocyte counts from disease severity in patients with acute-on-chronic liver failure. World J Gastroenterol 2026; In press

Received	2025-11-26 16:19
Peer-Review Started	2025-11-26 16:19
First Decision by Editorial Office Director	2026-01-15 07:18
Return for Revision	2026-01-15 07:18
Revised	2026-01-26 16:28
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 09:55
Articles in Press	2026-02-06 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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