Publication Name	World Journal of Hepatology
Manuscript ID	117040
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Multimarker model for non-invasive assessment of variceal bleeding in chronic hepatitis C cirrhotic patients
Manuscript Source	Invited Manuscript
All Author List	Amira Ahmed Abdelrahman Othman, Lamiaa Elsharkawy, Mohamed W Saleh, Mohamed Medhat Mohamed and Fatma M Attia Elsayed
Funding Agency and Grant Number
Corresponding Author	Amira Ahmed Abdelrahman Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Suez, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Thyroid dysfunction; Hepatitis C; Cirrhosis; Portal hypertension; International normalized ratio; Platelet count; Portal hemodynamics
Core Tip	This study validates a novel, non-invasive multimarker approach for identifying chronic hepatitis C cirrhotic patients at high risk for variceal bleeding. We identified a core panel of independent predictors: Low free triiodothyronine levels, low platelet count, and high international normalized ratio. A composite Variceal Risk Score integrating these with portal vein diameter demonstrated outstanding accuracy (area under the curve = 0.94). This strategy can efficiently triage patients for endoscopic screening, potentially reducing procedural burden in resource-limited settings.
Citation	Othman AAA, Elsharkawy L, Saleh MW, Mohamed MM, Elsayed FMA. Multimarker model for non-invasive assessment of variceal bleeding in chronic hepatitis C cirrhotic patients. World J Hepatol 2026; In press

Received	2025-11-27 01:08
Peer-Review Started	2025-11-27 01:08
First Decision by Editorial Office Director	2025-12-16 09:12
Return for Revision	2025-12-16 09:12
Revised	2025-12-17 03:06
Publication Fee Transferred
Second Decision by Editor	2026-01-22 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-22 06:09
Articles in Press	2026-01-22 06:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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