Publication Name	World Journal of Clinical Oncology
Manuscript ID	117055
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	PIGU overexpression and regulation of cellular biological functions in bladder cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Sheng-Hua Li, Zhi-Su Liu, Yu-Jia Chen, Jian-Di Li, Long Wei, Yi-Yang Chen, Wei Zhang, Zhi-Guang Huang, Zhen-Dong Chen, Gang Chen, Dan-Ming Wei, Zeng-Nan Mo and Li-Li Deng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. NSFC82260785 Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project No. Z20201168 Guangxi Medical University Digital Textbook Construction Project No. Gxmuszjc2515 Guangxi Medical University Special Project on Educational and Teaching Reform for Clinical Disciplines No. 2025LCJG02 Guangxi Medical University “Four New” Project No. SX202403 China Undergraduate Innovation and Entrepreneurship Training Program No. S202310598074
Corresponding Author	Li-Li Deng, PhD, Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. denglily2003@126.com
Key Words	PIGU; Bladder cancer; Immunohistochemistry; Cell cycle; Apoptosis; Prognosis; Immune infiltration
Core Tip	This study indicated that PIGU expression is markedly increased in bladder cancer at both the mRNA and protein levels and that this elevation serves as an independent predictor of unfavorable clinical outcomes. In vitro experiments further revealed that PIGU knockdown suppresses cell proliferation and induces apoptosis accompanied by G1-phase arrest, while mechanistic analyses indicated that PIGU facilitates tumor progression by regulating key cell cycle-related genes and modulating the immune microenvironment. These results indicate that PIGU could function not only as an independent prognostic indicator but also as a promising candidate for therapeutic targets.
Citation	Li SH, Liu ZS, Chen YJ, Li JD, Wei L, Chen YY, Zhang W, Huang ZG, Chen ZD, Chen G, Wei DM, Mo ZN, Deng LL. PIGU overexpression and regulation of cellular biological functions in bladder cancer. World J Clin Oncol 2026; In press

Received	2025-12-03 02:25
Peer-Review Started	2025-12-03 02:25
First Decision by Editorial Office Director	2025-12-09 08:49
Return for Revision	2025-12-09 08:49
Revised	2025-12-20 14:05
Publication Fee Transferred	2025-12-24 10:22
Second Decision by Editor	2026-02-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 08:18
Articles in Press	2026-02-10 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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