Publication Name	World Journal of Diabetes
Manuscript ID	117063
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Product of C-reactive protein and fasting C-peptide indicates cardiovascular risk in type 2 diabetes: A real-world study
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Wen Zhang, Man-Rong Xu, Meng-Han Li and Lian-Xi Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81770813 National Natural Science Foundation of China 82070866 the National Key Research and Development Plan 2018YFC1314905
Corresponding Author	Lian-Xi Li, MD, PhD, Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan Road, Shanghai 200233, China. lilx@sjtu.edu.cn
Key Words	Type 2 diabetes mellitus; C-reactive protein; C-peptide; Cardiovascular diseases; Risk factor; Real-world study
Core Tip	This study introduces the product of C-reactive protein and fasting C-peptide as a novel composite indicator. It better reflects the combined effects of inflammation and insulin resistance and shows more stable associations with cardiovascular and cerebrovascular events than either component alone in patients with type 2 diabetes mellitus, supporting its potential value as a composite marker reflecting the overall cardiovascular risk burden.
Citation	Zhang YW, Xu MR, Li MH, Li LX. Product of C-reactive protein and fasting C-peptide indicates cardiovascular risk in type 2 diabetes: A real-world study. World J Diabetes 2026; In press

Received	2025-11-28 01:15
Peer-Review Started	2025-12-01 09:05
First Decision by Editorial Office Director	2025-12-30 05:58
Return for Revision	2025-12-30 05:58
Revised	2026-01-08 21:57
Publication Fee Transferred	2026-01-13 11:07
Second Decision by Editor	2026-02-04 02:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 06:25
Articles in Press	2026-02-11 06:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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