Publication Name	World Journal of Psychiatry
Manuscript ID	117066
Country	China

Category	Neurosciences
Manuscript Type	Observational Study
Article Title	Circadian rhythm disruption alters gray and white matter microstructure: Higher-order diffusion analysis coupled with hormonal/inflammatory biomarkers
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Zhang, Wei-Yuan Huang, Lei Zhang, Zhuo-Ran Huang, Wei Zhao and Yong-Qiang Yu
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Huaibei City Science and Technology Plan Project HK2024057
Corresponding Author	Yong-Qiang Yu, PhD, Professor, Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230000, Anhui Province, China. yuyongqiang@ahmu.edu.cn
Key Words	Inflammatory factors; Endocrine; Neuroimaging; Diffusion spectrum imaging; Circadian rhythm disruption
Core Tip	This study focuses on female night-shift textile workers with circadian rhythm disruption (CRD), innovatively integrating diffusion spectrum imaging-based neurite orientation dispersion and density neuroimaging, endocrine/inflammatory biomarkers, and neuropsychological assessments. The study results reveal, for the first time, that neuroendocrine-immune crosstalk in CRD is mediated by neurostructural remodeling, dysregulation of the hypothalamic-pituitary-thyroid/hypothalamic-pituitary-gonadal axis, and neuroinflammation, providing critical evidence for precision diagnosis and intervention of CRD driven by multimodal biomarkers.
Citation	Zhang F, Huang WY, Zhang L, Huang ZR, Zhao W, Yu YQ. Circadian rhythm disruption alters gray and white matter microstructure: Higher-order diffusion analysis coupled with hormonal/inflammatory biomarkers. World J Psychiatry 2026; In press

Received	2025-12-02 08:09
Peer-Review Started	2025-12-02 08:09
First Decision by Editorial Office Director	2025-12-24 09:31
Return for Revision	2025-12-24 09:31
Revised	2026-01-07 02:39
Publication Fee Transferred	2026-01-09 08:31
Second Decision by Editor	2026-02-06 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 06:49
Articles in Press	2026-02-06 06:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com