Publication Name	World Journal of Psychiatry
Manuscript ID	117078
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ping Feng, Ze-Xuan Ji, Hong-Yan Zhang, Kai-Yan Song, Li-Ping Chen, Hai-Hong Qian and Bu Wang
Funding Agency and Grant Number	Funding Agency Grant Number Zhangjiakou Science and Technology Bureau No. 2322090D
Corresponding Author	Bu Wang, Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. fp202508@163.com
Key Words	Apple polyphenols; Acute exacerbation chronic obstructive pulmonary disease; Inflammatory; Anxiety-depression; NOD-like receptor protein 3
Core Tip	This study investigated the effects of apple polyphenols (AP) in a rat model of acute exacerbation of chronic obstructive pulmonary disease. Results demonstrated that AP treatment, particularly at high doses, effectively improved lung function and body weight and reduced pathological damage. It significantly downregulated the expression of NOD-like receptor protein 3 in lung tissue, leading to decreased levels of pro-inflammatory cytokines and oxidative stress markers in the serum, lung tissue, and prefrontal lobe tissue. Concurrently, AP alleviated anxiety and depression-like behaviors in acute exacerbation of chronic obstructive pulmonary disease model animals. This mechanism is associated with NOD-like receptor protein 3 pathway suppression.
Citation	Feng P, Ji ZX, Zhang HY, Song KY, Chen LP, Qian HH, Wang B. Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease. World J Psychiatry 2026; In press

Received	2026-01-09 10:03
Peer-Review Started	2026-01-09 10:03
First Decision by Editorial Office Director	2026-01-20 05:48
Return for Revision	2026-01-20 05:48
Revised	2026-02-09 09:34
Publication Fee Transferred	2026-02-13 12:21
Second Decision by Editor	2026-04-10 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-10 04:51
Articles in Press	2026-04-10 04:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com