Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117085
Country	China

Category	Oncology
Manuscript Type	Randomized Controlled Trial
Article Title	Impact of sintilimab with first-line therapy on tumor marker response in advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Liang Quan, Lin Xia, Yan Hu, Gui-Yuan Wang and Chao Wang
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Hefei BOE Hospital Institutional Research Project No. YJKT2024008 Anhui Provincial Higher Education Scientific Research Project (Natural Science Category) No. 2024AH050672
Corresponding Author	Chao Wang, Chief Physician, Department of Oncology, The Fourth Affiliated Hospital of Anhui Medical University, No. 64 Chaohu North Road, Hefei 238000, Anhui Province, China. wangchao10107@163.com
Key Words	Sintilimab; S-1 plus oxaliplatin regimen; Capecitabine plus oxaliplatin regimen; Advanced gastric cancer; Tumor markers; Carcinoembryonic antigen; Carbohydrate antigen 19-9; Carbohydrate antigen 72-4
Core Tip	This study demonstrated that sintilimab plus S-1 plus oxaliplatin/xeloda plus oxaliplatin regimen therapy significantly enhanced the reduction in tumor markers and improved tumor marker response rates in patients with advanced gastric cancer. The early and profound decrease in these markers showed a significant positive correlation with objective tumor shrinkage, highlighting their potential as valuable dynamic indicators for evaluating the efficacy of this immunochemotherapy combination.
Citation	Quan HL, Xia L, Hu Y, Wang GY, Wang C. Impact of sintilimab with first-line therapy on tumor marker response in advanced gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2025-12-02 09:39
Peer-Review Started	2025-12-02 09:39
First Decision by Editorial Office Director	2025-12-18 09:08
Return for Revision	2025-12-18 09:08
Revised	2025-12-29 11:56
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 11:02
Articles in Press	2026-02-06 11:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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