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Articles in Press
1/6/2026 12:41:50 AM | Browse: 136 | Download: 0
| Category |
Immunology |
| Manuscript Type |
Correspondence |
| Article Title |
Exosomal miR-191 activates the NF-κB pathway to drive M2 macrophages polarization in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amr Ahmed El-Arabey |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Deanship of Research and Graduate Studies at King Khalid University - Small Research Project |
RGP.1/260/46 |
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| Corresponding Author |
Amr Ahmed El-Arabey, Assistant Professor, Pharmacology, Toxicology and Clinical Pharmacy, King Khalid University, Nasr Road, Abha 61413, ‘Asīr, Saudi Arabia. ph.amrcapa@gmail.com |
| Key Words |
Exosomal miR-191; NF-κB pathway; M2 macrophage; Colorectal cancer; The Cancer Genomic Atlas |
| Core Tip |
Exosomal miR-191 is becoming a crucial pathway of how inflammatory signaling works within tumor microenvironment of colorectal cancer. By activating NF-κB, miR-191 can change the tumor microenvironment to make it immunosuppressive and pro-angiogenic, via shifting the polarization into M2 macrophages. Utilizing The Cancer Genomic Atlas data analyzed via tumor immune estimation resource, version 3, NF-κB1 expression correlated positively with M2 macrophage infiltration, whereas NF-κB1 -mutant tumors had lower macrophage infiltration. Elevated M2 infiltration predicted a shorter disease-free duration in the NF-κB1-high sample, indicating a context-dependent prognostic factor and highlighting the miR-191/NF-κB/M2 macrophages axis as a therapeutic target. |
| Citation |
El-Arabey AA. Exosomal miR-191 activates the NF-κB pathway to drive M2 macrophages polarization in colorectal cancer. World J Gastrointest Oncol 2026; 18(6): 117110
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Received |
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2025-11-28 00:46 |
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Peer-Review Started |
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2025-11-28 05:58 |
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First Decision by Editorial Office Director |
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2025-12-17 08:04 |
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Return for Revision |
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2025-12-17 08:04 |
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Revised |
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2025-12-20 17:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-05 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-06 00:41 |
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Articles in Press |
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2026-01-06 00:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-11 09:14 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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