Publication Name	World Journal of Diabetes
Manuscript ID	117113
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Leptin hypomethylation: An early epigenetic marker associated with lean-type diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Zhong-Yi Zhao, Pan-Feng Wu and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author	Nian-Zhe Sun, MD, PhD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words	Epigenetic gene regulation; Lean type 2 diabetes; Leptin; DNA methylation; Disease progression prediction
Core Tip	Epigenetic dysregulation of leptin (LEP) gene in lean Chinese patients with diabetes has been understudied. Sun et al performed a cross-sectional study to investigate the associations of LEP promoter methylation levels and serum leptin concentrations with diabetes progression in non-obese individuals (body mass index < 24 kg/m²). Findings indicated that in lean adult Chinese patients (body mass index < 24 kg/m²), the methylation of the LEP promoter gradually decreased during the progression of diabetes, demonstrating a significant inverse correlation with serum leptin levels. These findings imply that LEP promoter methylation may act as a potential biomarker for early risk stratification of diabetes and prediction of its severity in non-obese patients with diabetes.
Citation	Zhao ZY, Wu PF, Sun NZ. Leptin hypomethylation: An early epigenetic marker associated with lean-type diabetes. World J Diabetes 2026; In press

Received	2025-12-05 01:46
Peer-Review Started	2025-12-05 08:36
First Decision by Editorial Office Director	2025-12-30 05:58
Return for Revision	2025-12-30 05:58
Revised	2026-01-06 14:26
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 07:38
Articles in Press	2026-02-05 07:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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