Publication Name	World Journal of Gastroenterology
Manuscript ID	117115
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Yuan Wang, Ke-Han Yin, Li Cheng, Xiao-Yu Wang, Ying Qiao, Xing-Ru Tang, Bo Wang, Xiu-Juan Yan and Sheng-Liang Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82570628 National Natural Science Foundation of China 82170554 National Natural Science Foundation of China 82300643
Corresponding Author	Sheng-Liang Chen, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China. chenslmd@shsmu.edu.cn
Key Words	Flupentixol-melitracen; Functional dyspepsia; Lansoprazole; Anxiety; Deanxit
Core Tip	This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of flupentixol-melitracen combined with lansoprazole for functional dyspepsia (FD). our study demonstrated that this low-dose short-term regimen not only improved FD symptoms and quality of life within two weeks but also sustained efficacy for four weeks post-treatment. Future long-term follow-up and multicenter studies are warranted to verify its lasting benefits and health economic value, potentially advancing FD management from a “stepwise sequential” approach to a “brain-gut co-management” therapy.
Citation	Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; In press

Received	2025-12-01 01:07
Peer-Review Started	2025-12-01 01:07
First Decision by Editorial Office Director	2026-01-07 09:24
Return for Revision	2026-01-07 09:24
Revised	2026-01-19 10:22
Publication Fee Transferred	2026-01-20 13:07
Second Decision by Editor	2026-02-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 08:14
Articles in Press	2026-02-12 08:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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