Publication Name	World Journal of Experimental Medicine
Manuscript ID	117125
Country	India

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Randomized Clinical Trial
Article Title	Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial
Manuscript Source	Invited Manuscript
All Author List	Subash Chandra Raj, Sudip Sen, Debajani Baral, Devapratim Mohanty, Shaheda Tabassum, Swoyangprava Sil and Mrutyunjaya Sahu
Funding Agency and Grant Number
Corresponding Author	Subash Chandra Raj, Full Professor, Head, Department of Periodontics, SCB Dental College and Hospital, Mangalabag Road, cuttack 753003, Odisha, India. drsubash007@gmail.com
Key Words	Periodontitis; Scaling and root planing; Photodynamic therapy; Nanoparticles; Chitosan; Indocyanine green
Core Tip	This trial assesses the adjunctive use of indocyanine green-doped chitosan nanoparticles (CNPs-ICG) in antimicrobial photodynamic therapy (aPDT) with scaling and root planing (SRP) for periodontitis management. Conducted at SCB Dental College and Hospital, Cuttack, on 30 patients, the trial demonstrated significantly superior clinical and microbiological outcomes-particularly in improvement in probing depth, gain in clinical attachment level, and bacterial elimination-in comparison to conventional SRP alone. CNPs-ICG enhanced biofilm targeting and treatment precision through improved photosensitizer delivery. The findings highlight aPDT with CNPs-ICG as an effective, non-surgical, and minimally invasive alternative for patients unsuitable for periodontal surgery.
Citation	Raj SC, Sen S, Baral D, Mohanty D, Tabassum S, Sil S, Sahu M. Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial. World J Exp Med 2026; In press

Received	2025-12-01 00:48
Peer-Review Started	2025-12-01 00:48
First Decision by Editorial Office Director	2025-12-17 09:31
Return for Revision	2025-12-17 09:31
Revised	2025-12-22 06:37
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 08:42
Articles in Press	2026-02-03 08:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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