Publication Name	World Journal of Clinical Cases
Manuscript ID	117140
Country	India

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Endocrine consequences of antifungal therapy: A missed entity
Manuscript Source	Invited Manuscript
All Author List	Simran Thakkar, Viny Kantroo, Lakshmi Nagendra, Deep Dutta, Abul Bashar Mohammad Kamrul-Hasan, Sanjay Kalra and Saptarshi Bhattacharya
Funding Agency and Grant Number
Corresponding Author	Saptarshi Bhattacharya, DM, MD, Department of Endocrinology, Indraprastha Apollo Hospitals, Delhi Mathura Road, New Delhi 110076, Delhi, India. saptarshi515@gmail.com
Key Words	Voriconazole; Posaconazole; Adrenal insufficiency; Apparent mineralocorticoid excess; Ketoconazole; Amphotericin B; Antifungal therapy
Core Tip	Antifungal drugs can interfere with key endocrine pathways by inhibiting steroidogenic enzymes or through drug–drug interactions that alter glucocorticoid and mineralocorticoid metabolism. Ketoconazole, fluconazole, itraconazole, posaconazole, and voriconazole demonstrate distinct endocrine adverse effects, ranging from adrenal insufficiency and apparent mineralocorticoid excess to reproductive dysfunction, hyponatremia, and fluoride-related periostitis. Amphotericin B primarily acts through renal tubular injury and associated electrolyte disturbances, whereas echinocandins rarely affect endocrine function. Recognizing these effects, especially in patients receiving multiple interacting medications, is essential for timely diagnosis and safe therapeutic decision-making.
Citation	Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2025; In press

Received	2025-12-01 00:44
Peer-Review Started	2025-12-01 00:44
First Decision by Editorial Office Director	2025-12-04 08:57
Return for Revision	2025-12-04 08:57
Revised	2025-12-15 19:02
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 08:56
Articles in Press	2025-12-25 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com