Publication Name	World Journal of Gastroenterology
Manuscript ID	117149
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Modified Hulianbiguan decoction for wound healing in complex anal fistula: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Han-Wen Yang, Ting-Ting Li, Xin-Bo Song, Li-Xia Lai, Qiang Yu, Huang-Fu Ma, Yue Wang, Xue-Cheng Zhang, Xiao-Yu Chen, Shu-Xin Zhang and Jia-Nan Li
Funding Agency and Grant Number	Funding Agency Grant Number the National High Level Hospital Clinical Research Funding 2023-NHLHCRF-YYPPLC-ZR-03 National High Level Hospital Clinical Research Funding, Elite Medical Professionals Initiative of the China-Japan Friendship Hospital ZRJY2025-QM11
Corresponding Author	Jia-Nan Li, Department of Proctology, China-Japan Friendship Hospital, No. 2, Yingyuan Garden East Street, Chaoyang District, Beijing, Beijing 100029, China. wuqu3@163.com
Key Words	Modified Hu-Lian-Bi-Guan decoction; Complex anal fistula; TGF-β/Smad signaling pathway; Epithelial-mesenchymal transition; Inflammatory factors
Core Tip	This randomized controlled trial evaluates the efficacy of modified Hu-Lian-Bi-Guan decoction (mHLBGD) in enhancing postoperative wound healing for complex anal fistula (AF). The study demonstrates that mHLBGD significantly accelerates healing time and reduces postoperative pain compared to standard care. Mechanistically, the research highlights that mHLBGD promotes tissue repair by modulating inflammatory cytokines, regulating the TGF-β/Smad signaling pathway, and influencing epithelial-mesenchymal transition. These findings provide compelling clinical and molecular evidence supporting mHLBGD as an effective adjunctive therapy for complex AF recovery.
Citation	Yang HW, Li TT, Song XB, Lai LX, Yu Q, Ma HF, Wang Y, Zhang XC, Chen XY, Zhang SX, Li JN. Modified Hulianbiguan decoction for wound healing in complex anal fistula: A randomized controlled trial. World J Gastroenterol 2026; In press

Received	2025-12-02 09:35
Peer-Review Started	2025-12-02 09:35
First Decision by Editorial Office Director	2025-12-23 10:10
Return for Revision	2025-12-23 10:10
Revised	2026-01-03 04:35
Publication Fee Transferred	2026-01-05 11:50
Second Decision by Editor	2026-01-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 08:16
Articles in Press	2026-01-12 08:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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