Publication Name	World Journal of Gastroenterology
Manuscript ID	117151
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	From traditional formula to modern mechanism: How Anwei decoction alleviates chronic atrophic gastritis via regulating the gut-stomach axis
Manuscript Source	Invited Manuscript
All Author List	Wen-Xin Dai, Hao-Wei Li, Wei Guo, Li-Yun Zheng and Huo-Xiang Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Key Scientific and Technological Project of Henan Province 242102310041, 252102310044 Basic Research Foundation of Henan Institute of Medical and Pharmacological Sciences 2024BP0301
Corresponding Author	Huo-Xiang Zhou, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, No. 40 North Daxue Road, Zhengzhou 450052, Henan province, China. huoxiang_zhou@zzu.edu.cn
Key Words	Traditional Chinese medicine; Anwei decoction; Chronic atrophic gastritis; Gut microbiota; NLR family pyrin domain containing 3 inflammasome
Core Tip	Chronic atrophic gastritis (CAG) is a precancerous condition, while no treatments are currently available for this disease that can reverse its progression. Qin et al’s study revealed that the traditional Chinese medicine formula Anwei decoction alleviated CAG through directly inhibiting NLR family pyrin domain containing 3 inflammasome activity and reshaping the gut microbiota-metabolite axis. Their research marked the first systematic elucidation of the biological mechanism through which Anwei decoction mediated its therapeutic effects via the “gut-stomach axis”. The findings provided cogent evidence for the efficacy of traditional Chinese medicine for CAG and highlighted the promise of multi-omics integration in revealing how traditional medical formulas are effective.
Citation	Dai WX, Li HW, Guo W, Zheng LY, Zhou HX. From traditional formula to modern mechanism: How Anwei decoction alleviates chronic atrophic gastritis via regulating the gut-stomach axis. World J Gastroenterol 2026; In press

Received	2025-12-01 03:15
Peer-Review Started	2025-12-03 09:12
First Decision by Editorial Office Director	2025-12-25 08:50
Return for Revision	2025-12-25 08:50
Revised	2026-01-07 11:07
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 08:53
Articles in Press	2026-02-25 08:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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