Publication Name	World Journal of Clinical Cases
Manuscript ID	117167
Country	Greece

Category	Neurosciences
Manuscript Type	Retrospective Study
Article Title	Correlation between esmolol usage in the acute phase of ischemic stroke and outcomes of patients undergoing intravenous thrombolysis
Manuscript Source	Invited Manuscript
All Author List	Panagiotis Papamichalis, Sophia K Papathanasiou, Apostolia Lemonia Skoura, Katerina G Oikonomou, Maria Xanthoudaki, Antonios Papadogoulas, Asimina Valsamaki, Dimitrios Plageras, Michail Papamichalis, Periklis Katsiafylloudis, Evangelia Papapostolou, Konstantinos Mantzarlis, Athanasios Koukoulis, Georgios D Koukoulis, Kyriaki Parisi, Grigorios Papapostolou, Vasileios Siokas, Efthimios Dardiotis and Achilleas Chovas
Funding Agency and Grant Number
Corresponding Author	Panagiotis Papamichalis, MD, PhD, Intensive Care Unit, General Hospital of Larissa, 1 Tsakalof, Larissa 41221, Thessaly, Greece. ppapamih@med.uth.gr
Key Words	Thrombolysis; Alteplase; Esmolol; Arterial blood pressure; Complications; Mortality; Functional outcome
Core Tip	Various drugs, including esmolol, are used for managing elevated arterial blood pressure before intravenous thrombolysis for acute ischemic stroke. This study evaluated baseline characteristics and outcomes of 149 patients with a focus on esmolol-treated and esmolol-untreated groups. Sub-group analysis was performed to compare the outcomes between the esmolol-treated and esmolol-untreated subgroups among the following patient groups: Patients with atrial fibrillation (AF); patients without AF; patients with a history of hypertension; patients without a history of hypertension. Esmolol usage resulted in poor outcomes for the overall cohort, patients without AF, and patients without a history of hypertension but not for patients with AF and patients with a history of hypertension.
Citation	Papamichalis P, Papathanasiou SK, Skoura AL, Oikonomou KG, Xanthoudaki M, Papadogoulas A, Valsamaki A, Plageras D, Papamichalis M, Katsiafylloudis P, Papapostolou E, Mantzarlis K, Koukoulis A, Koukoulis GD, Parisi K, Papapostolou G, Siokas V, Dardiotis E, Chovas A. Correlation between esmolol usage in the acute phase of ischemic stroke and outcomes of patients undergoing intravenous thrombolysis. World J Clin Cases 2026; In press

Received	2025-12-01 03:12
Peer-Review Started	2025-12-01 03:12
First Decision by Editorial Office Director	2026-01-20 08:25
Return for Revision	2026-01-20 08:25
Revised	2026-01-31 15:23
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 08:22
Articles in Press	2026-02-25 08:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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