| Category |
Psychology, Clinical |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Alcohol dehydrogenase 4 expression in hepatocellular carcinoma and its association with tumor invasion, survival, and psychological status
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian Xia, Cheng-Li Liu, Jing-Chen Zhang, Pu Meng, Ying-Bo Ma, Qi-Ke Huang, Hao-Ming Li, Xu-Ying Zhao, Cheng Wang, Gang Zhao and Ling-Hong Kong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Capital Health Development Research Special Project of 2024 |
No. SF-2024-2-5121 |
|
| Corresponding Author |
Cheng-Li Liu, MD, Department of Hepatobiliary Surgery, Air Force Medical Center, Graduate School of Hebei North University, Hebei North University, No. 11 Diamond South Road, Qiaodong District, Zhangjiakou 075031, Hebei Province, China. liuchengli_beijing@163.com |
| Key Words |
Hepatocellular carcinoma; Alcohol dehydrogenase 4; Tumor invasiveness; Prognosis; Anxiety; Depression |
| Core Tip |
Low alcohol dehydrogenase 4 (ADH4) expression in hepatocellular carcinoma correlates with larger tumors, poor differentiation, high microvascular invasion, reduced 1-year and 3-year survival, and elevated anxiety-depression scores. Multivariate analysis identifies low ADH4 as an independent poor prognostic factor. These findings suggest ADH4 is a valuable biomarker for assessing tumor aggressiveness, predicting outcomes, and identifying patients requiring intensive therapy and psychosocial support, thus enabling personalized oncological and mental-health interventions to improve overall prognosis and quality of life. |
| Citation |
Xia T, Liu CL, Zhang JC, Meng P, Ma YB, Huang QK, Li HM, Zhao XY, Wang C, Zhao G, Kong LH. Alcohol dehydrogenase 4 expression in hepatocellular carcinoma and its association with tumor invasion, survival, and psychological status. World J Psychiatry 2026; In press |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
