Publication Name	World Journal of Critical Care Medicine
Manuscript ID	117211
Country	Brazil

Category	Critical Care Medicine
Manuscript Type	Observational Study
Article Title	High-density lipoprotein-cholesterol and triglyceride levels and their prognosis in critically ill septic patients
Manuscript Source	Invited Manuscript
All Author List	Wagner Nedel, Lílian R Henrique, João Alberto S Deuschle, Luiz H de Oliveira, Laura V de Lima, Giovana T Jahnke and Luis V Portela
Funding Agency and Grant Number
Corresponding Author	Wagner Nedel, Assistant Professor, MD, PhD, Department of Intensive Care Unit, Conceição Hospital Group, Francisco Trein 596, Segundo Andar, Porto Alegre 91350200, Brazil. wagnernedel@gmail.com
Key Words	Sepsis; High-density lipoprotein; Triglycerides; Immunologic resposnse; Sequential organ failure assessment; Interleukins; Mitochondrial metabolism
Core Tip	High-density lipoprotein (HDL) and triglyceride (TG) should be considered inflammatory biomarkers in sepsis, yet they exhibit distinct characteristics in the early response to the condition. TG levels correlate with patient severity upon intensive care unit admission, while lower HDL levels at the time of sepsis diagnosis are slightly linked to higher mortality. However, an early improvement in HDL does not correlate with better outcomes. Nonetheless, both biomarkers are associated with levels of significant inflammatory markers in sepsis, such as interleukin-10 and C-reactive protein.
Citation	Nedel W, Henrique LR, Deuschle JAS, de Oliveira LH, de Lima LV, Jahnke GT, Portela LV. High-density lipoprotein-cholesterol and triglyceride levels and their prognosis in critically ill septic patients. World J Crit Care Med 2026; In press

Received	2025-12-02 01:08
Peer-Review Started	2025-12-02 01:08
First Decision by Editorial Office Director	2026-01-07 02:11
Return for Revision	2026-01-07 02:11
Revised	2026-01-16 04:53
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 08:15
Articles in Press	2026-02-04 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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