Publication Name	World Journal of Methodology
Manuscript ID	117220
Country	India

Category	Anesthesiology
Manuscript Type	Randomized Controlled Trial
Article Title	Comparison of propofol alone vs propofol-phenylephrine combination for intraoperative hemodynamic stability in glioma surgery
Manuscript Source	Invited Manuscript
All Author List	Rhea Thotungal, Ashutosh Kaushal, Amit Agrawal, Anuj Jain, Vaishali Waindeskar, Rudrashish Haldar and Pfokreni Lokho
Funding Agency and Grant Number
Corresponding Author	Ashutosh Kaushal, Additional Professor, DM, MD, Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462026, Madhya Pradesh, India. drashutosh.kaushal@gmail.com
Key Words	Propofol; Phenylephrine; Hemodynamic stability; Glioma surgery; Induction of anesthesia; Neuroanesthesia; Brain relaxation
Core Tip	Propofol is widely preferred for the induction and maintenance in neuroanesthesia due to its neuroprotective properties. However, propofol frequently causes hypotension during the induction of anesthesia in neurosurgical patients, which may compromise cerebral perfusion. Therefore, combining phenylephrine with propofol significantly reduces induction-related hypotension, minimizes vasopressor requirement, and maintains stable intraoperative hemodynamics without affecting brain relaxation, offering a practical approach for neuroanesthesia in glioma surgery.
Citation	Thotungal R, Kaushal A, Agrawal A, Jain A, Waindeskar V, Haldar R, Lokho P. Comparison of propofol alone vs propofol-phenylephrine combination for intraoperative hemodynamic stability in glioma surgery. World J Methodol 2026; In press

Received	2025-12-08 01:05
Peer-Review Started	2025-12-08 01:05
First Decision by Editorial Office Director	2025-12-12 09:08
Return for Revision	2025-12-12 09:08
Revised	2025-12-14 10:20
Publication Fee Transferred
Second Decision by Editor	2026-03-16 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-16 09:00
Articles in Press	2026-03-16 09:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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