Publication Name	World Journal of Diabetes
Manuscript ID	117228
Country	China

Category	Dermatology
Manuscript Type	Editorial
Article Title	Fractional carbon dioxide laser preconditioning potentiates adipose-derived mesenchymal stem cell exosomes for diabetic wound repair
Manuscript Source	Invited Manuscript
All Author List	Chun-Yi Wu, Xie-Hua Xiao and Jian-Guo Feng
Funding Agency and Grant Number	Funding Agency Grant Number Sichuan Science and Technology Program No. 2025ZNSFSC0744 Health Commission of Sichuan Province Medical Science and Technology Program No. 24QNMP040 Luzhou Science and Technology Program No. 2025RCX002
Corresponding Author	Jian-Guo Feng, Associate Professor, PhD, Principal Investigator, Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, No.25th, Taiping Street, Luzhou, Luzhou 646000, Sichuan Province, China. fengjianguo@swmu.edu.cn
Key Words	Angiogenesis.; Preconditioning; Fractional carbon dioxide laser; Exosomes; Mesenchymal stem cells; Diabetic wound healing
Core Tip	This editorial highlight that fractional carbon dioxide (CO₂) laser pre-conditioning offers a novel, drug-free strategy to enhance the therapeutic quality of adipose-derived mesenchymal stem cell exosomes (Exos) for diabetic wound repair. We emphasize recent findings that this physical pre-conditioning strategy, utilizing clinically established and dose-tunable photothermal stimulation, enriches sphingosine-1-phosphate (S1P) cargo and activates endothelial S1P receptor 1/protein kinase B/hypoxia-inducible factor-1α signaling, thereby promoting improved angiogenesis and cytoprotection. This concept reframes fractional CO₂ lasers as a scalable, good manufacturing practice-compatible platform to “upgrade” Exos bioactivity for chronic diabetic wounds.
Citation	Wu CY, Xiao XH, Feng JG. Fractional carbon dioxide laser preconditioning potentiates adipose-derived mesenchymal stem cell exosomes for diabetic wound repair. World J Diabetes 2026; In press

Received	2025-12-02 00:57
Peer-Review Started	2025-12-03 09:18
First Decision by Editorial Office Director	2025-12-31 07:54
Return for Revision	2025-12-31 07:54
Revised	2026-01-14 03:34
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 12:06
Articles in Press	2026-02-04 12:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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