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Articles in Press
3/19/2026 7:23:16 AM | Browse: 5 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Midlife intervention of Dendrobium officinale extract modulates gut microbiota to activate InR-Nrf2 axis, promoting intestinal health and longevity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen-Rong Jin, Jiao Xi, Si-Ming Wang, Si-Yu Zhang, Shi-Ting Yu, Dai-An Pan, Da-Qing Zhao, Zheng-Qi Dong, Shi-Chao Liu and Mei-Chen Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific and Technological Development Planning Foundation of Jilin Province |
No. YDZJ202401009ZYTS |
| National Natural Science Foundation of China |
No. 82404836 |
| Scientific and Technological Developing Scheme of Jilin Province |
No. 20210304002YY |
| Scientific and Technological Developing Scheme of Jilin Province |
No. 20210204188YY |
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| Corresponding Author |
Mei-Chen Liu, PhD, Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, No. 1035 Boshuo Road, Changchun 130000, Jilin Province, China. liumc@ccucm.edu.cn |
| Key Words |
Aging; Antioxidants; Caenorhabditis elegans; Drosophila melanogaster; Gut microbiota |
| Core Tip |
Dendrobium officinale extract intervention during middle age is the optimal window for cross-species conservation of its benefits, delaying degeneration and extending lifespan. It maintains intestinal stem cell homeostasis and remodels gut microbiota, promoting gender-specific microbe-host pairings (Acetobacter pomorum in females, Lactobacillus plantarum in males) to modulate metabolic differences. This reshaped microbiota activates the InR-Nrf2 axis, antagonizing oxidative stress, ensuring intestinal homeostasis, and prolonging health span. |
| Citation |
Jin CR, Xi J, Wang SM, Zhang SY, Yu ST, Pan DA, Zhao DQ, Dong ZQ, Liu SC, Liu MC. Midlife intervention of Dendrobium officinale extract modulates gut microbiota to activate InR-Nrf2 axis, promoting intestinal health and longevity. World J Gastroenterol 2026; In press |
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Received |
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2025-12-05 01:16 |
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Peer-Review Started |
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2025-12-05 01:16 |
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First Decision by Editorial Office Director |
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2026-01-07 09:29 |
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Return for Revision |
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2026-01-07 09:29 |
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Revised |
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2026-01-28 22:36 |
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Publication Fee Transferred |
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2026-01-30 01:40 |
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Second Decision by Editor |
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2026-03-19 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-19 07:23 |
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Articles in Press |
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2026-03-19 07:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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