Publication Name	World Journal of Gastroenterology
Manuscript ID	117240
Country	Austria

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Real-world inflammatory bowel disease-modification outcomes: A narrative review
Manuscript Source	Unsolicited Manuscript
All Author List	Neeraj Narula, Shashi Adsul and Walter Reinisch
Funding Agency and Grant Number
Corresponding Author	Walter Reinisch, MD, PhD, Department of Medicine III, Division for Gastroenterology and Hepatology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna A-1090, Austria. walter.reinisch@meduniwien.ac.at
Key Words	Crohn’s disease; Disease modification; Inflammatory bowel disease; Real-world evidence; Standard protocol items: Recommendations for interventional trials consensus; Ulcerative colitis
Core Tip	The standard protocol items: Recommendations for interventional trials (SPIRIT) consensus has recommended disease-modification endpoints for use in clinical trials in patients with inflammatory bowel disease (IBD) to help determine if this approach can prevent disease progression. Before such studies are conducted, real-world evidence can be informative. This review of real-world studies utilizing the SPIRIT consensus endpoints identified considerable gaps in the use of these recommended disease-modification endpoints. Therefore, there remains a need to incorporate SPIRIT recommended disease-modification endpoints in prospective real-world studies in patients with IBD receiving advanced treatments.
Citation	Narula N, Adsul S, Reinisch W. Real-world inflammatory bowel disease-modification outcomes: A narrative review. World J Gastroenterol 2026; In press

Received	2025-12-02 02:22
Peer-Review Started	2025-12-02 02:22
First Decision by Editorial Office Director	2025-12-17 10:17
Return for Revision	2025-12-17 10:17
Revised	2026-03-05 01:47
Publication Fee Transferred
Second Decision by Editor	2026-07-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 03:15
Articles in Press	2026-07-27 03:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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