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Publication Name World Journal of Psychiatry
Manuscript ID 117245
Country China
Category Psychiatry
Manuscript Type Case Control Study
Article Title Neural correlates of impairments in music emotion processing in major depressive disorder: Evidenced from an event-related potential study
Manuscript Source Unsolicited Manuscript
All Author List Ya-Nan He, Wen-Yu Yang, Jing Zhang, Xin-Yu Wang, Xue-Zheng Gao, Xiao-Hong Liu and Zhen-He Zhou
Funding Agency and Grant Number
Funding Agency Grant Number
Wuxi Taihu Talent Project WXTTP2021
Corresponding Author Zhen-He Zhou, Chief Physician, MD, PhD, Professor, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Wuxi 214151, Jiangsu Province, China. zhouzh@njmu.edu.cn
Key Words Major depressive disorder; Emotional processing; Musical emotional information; Event-related potentials; N100; P200; P300
Core Tip Using ecologically valid traditional Chinese instrumental music as stimuli and multi-stage event-related potentials analysis, this study found that patients with major depressive disorder exhibit multi-stage abnormalities in musical emotion processing: Enhanced central N100 amplitude (early sensory hypervigilance), failure of P200 to distinguish neutral from negative music (feature discrimination deficit), and absence of P300 emotional modulation (impaired late cognitive evaluation), accompanied by lower behavioral accuracy and longer reaction times. These event-related potentials profiles may serve as potential neurobiological markers for cognitive impairments in major depressive disorder.
Citation

He YN, Yang WY, Zhang J, Wang XY, Gao XZ, Liu XH, Zhou ZH. Neural correlates of impairments in music emotion processing in major depressive disorder: Evidenced from an event-related potential study. World J Psychiatry 2026; 16(5): 117245

Received
2025-12-03 01:36
Peer-Review Started
2025-12-03 01:36
First Decision by Editorial Office Director
2026-01-15 09:36
Return for Revision
2026-01-15 09:36
Revised
2026-01-27 15:09
Publication Fee Transferred
2026-01-29 01:15
Second Decision by Editor
2026-02-26 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-26 08:18
Articles in Press
2026-02-26 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-16 03:55
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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