Publication Name	World Journal of Psychiatry
Manuscript ID	117251
Country	China

Category	Psychology, Clinical
Manuscript Type	Retrospective Cohort Study
Article Title	Goal-directed fluid therapy and cognitive outcomes in elderly surgical patients with anxiety and depression
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Li, Jin-Liang Teng, Li Yuan and Lei Han
Funding Agency and Grant Number	Funding Agency Grant Number the Zhangjiakou Municipal Bureau of Science and Technology No. 2311041D
Corresponding Author	Lei Han, Chief Physician, Department of Anesthesiology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, No. 3 Yongding Road East Street, Haidian District, Beijing 100039, China. lee91192025@163.com
Key Words	Goal-directed fluid therapy; Postoperative cognitive dysfunction; Cerebral oxygen saturation; Anxiety and depression; Elderly patients
Core Tip	This study demonstrates that goal-directed fluid therapy significantly improves perioperative cerebral oxygen supply-demand balance and reduces postoperative cognitive dysfunction in elderly surgical patients. The protective effect is especially strong in patients with preoperative anxiety and depression, a high-risk population with impaired cerebrovascular regulation and altered oxygen metabolism. By stabilizing hemodynamics and preserving regional cerebral oxygen saturation, goal-directed fluid therapy promotes both cognitive recovery and improvements in psychological status, highlighting its value for precision perioperative brain protection.
Citation	Li H, Teng JL, Yuan L, Han L. Goal-directed fluid therapy and cognitive outcomes in elderly surgical patients with anxiety and depression. World J Psychiatry 2026; In press

Received	2025-12-09 09:20
Peer-Review Started	2025-12-09 09:21
First Decision by Editorial Office Director	2025-12-31 07:25
Return for Revision	2025-12-31 07:25
Revised	2026-01-16 15:13
Publication Fee Transferred	2026-01-23 09:25
Second Decision by Editor	2026-03-24 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-24 07:56
Articles in Press	2026-03-24 07:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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