Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117252
Country	Türkiye

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Storax oil and boron compounds trigger apoptosis and cell cycle arrest in gastric and colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Buket Er Urganci, Sacide Çakal, Cihangir Dogan, Sibel Göçmen, Selda Şimşek and Sevda Yılmaz
Funding Agency and Grant Number
Corresponding Author	Buket Er Urganci, Assistant Professor, Department of Medical Biology, Faculty of Medicine, Pamukkale University, Morphology Building, 3rd Floor, Denizli 20160, Türkiye. aber@pau.edu.tr
Key Words	Gastric cancer; Colorectal cancer; Liquidambar oil; Boric acid; Borax; Apoptosis
Core Tip	This study demonstrates that storax oil, boric acid, and borax exert strong anticancer activity in gastric and colorectal cancer cells. Treatments significantly induced apoptosis by upregulating p53, Bax, and caspases, while suppressing Bcl-2. Boron compounds enhanced cell cycle arrest via increased p21 and decreased CyclinD1 expression. Notably, combination treatments showed synergistic effects, producing greater apoptotic and anti-proliferative responses than individual agents. These findings highlight the potential of storax oil and boron derivatives as complementary therapeutic strategies, offering new insights into apoptosis and cell cycle regulation in gastrointestinal cancers.
Citation	Er Urganci B, Çakal S, Dogan C, Göçmen S, Şimşek S, Yılmaz S. Storax oil and boron compounds trigger apoptosis and cell cycle arrest in gastric and colorectal cancer. World J Gastrointest Oncol 2026; In press

Received	2025-12-03 01:55
Peer-Review Started	2025-12-03 01:55
First Decision by Editorial Office Director	2025-12-17 10:19
Return for Revision	2025-12-17 13:17
Revised	2025-12-19 13:20
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 07:38
Articles in Press	2026-02-09 07:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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