Publication Name	World Journal of Clinical Cases
Manuscript ID	117257
Country	India

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	Ocular health in outer space and beyond gravity: A minireview
Manuscript Source	Invited Manuscript
All Author List	Srishti Khullar, Arvind Kumar Morya, Sarita Aggarwal, Twinkle Gupta, Priyanka Priyanka and Rannusha Morya
Funding Agency and Grant Number
Corresponding Author	Arvind Kumar Morya, Additional Professor, Consultant, Principal Investigator, Researcher, Senior Researcher, Department of Ophthalmology, All India Institute of Medical Sciences, Bibi Nagar, Hyderabad 508126, Telangāna, India. bulbul.morya@gmail.com
Key Words	Spaceflight-associated neuro-ocular syndrome; Microgravity; Intracranial pressure; Ocular health; Astronaut physiology; Space medicine
Core Tip	Vision is mission-critical in human spaceflight. Prolonged exposure to microgravity causes a distinct set of ocular changes known as spaceflight-associated neuro-ocular syndrome. These include optic disc edema, posterior globe flattening, choroidal folds, retinal nerve fiber layer thickening, and hyperopic refractive shifts. Evidence suggests spaceflight-associated neuro-ocular syndrome arises from cephalad fluid shifts, venous congestion, and altered cerebrospinal fluid dynamics rather than raised intracranial pressure alone. Advances in in-flight imaging and artificial intelligence are improving early detection, making ocular health central to safe space exploration and neuro-ophthalmic research.
Citation	Khullar S, Morya AK, Aggarwal S, Gupta T, Priyanka P, Morya R. Ocular health in outer space and beyond gravity: A minireview. World J Clin Cases 2025; In press

Received	2025-12-03 01:10
Peer-Review Started	2025-12-03 01:10
First Decision by Editorial Office Director	2025-12-09 08:37
Return for Revision	2025-12-09 08:37
Revised	2025-12-17 08:37
Publication Fee Transferred
Second Decision by Editor	2025-12-26 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-26 08:29
Articles in Press	2025-12-26 08:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com