Publication Name	World Journal of Stem Cells
Manuscript ID	117271
Country	India

Category	Cell & Tissue Engineering
Manuscript Type	Review
Article Title	Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Anandanarayan Muruganandam, Naveen Jeyaraman, Ashika Mudilikulam Sukumaran, Swaminathan Ramasubramanian, Viji Devanand, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Bone marrow; Mesenchymal stromal cell; Secretomes; Osteoarthritis; Therapeutics
Core Tip	Mesenchymal stromal cell-derived secretomes, rich in exosomes, cytokines, and growth factors, offer a cell-free therapeutic strategy for knee osteoarthritis by modulating inflammation, promoting chondroprotection, and restoring subchondral bone homeostasis. Their paracrine-driven mechanisms target multiple pathological pathways simultaneously, surpassing symptomatic treatments. However, clinical translation demands rigorous standardization, optimized delivery systems, and clear regulatory frameworks to unlock their full regenerative potential in osteoarthritis management.
Citation	Muruganandam A, Jeyaraman N, Sukumaran MA, Ramasubramanian S, Devanand V, Nallakumarasamy A, Muthu S, Jeyaraman M. Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis. World J Stem Cells 2026; In press

Received	2025-12-03 01:17
Peer-Review Started	2025-12-03 01:17
First Decision by Editorial Office Director	2025-12-16 07:13
Return for Revision	2025-12-16 07:13
Revised	2025-12-20 11:16
Publication Fee Transferred
Second Decision by Editor	2026-02-02 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 10:56
Articles in Press	2026-02-04 10:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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