Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	117283
Country	Egypt

Category	Medicine, Research & Experimental
Manuscript Type	Case Control Study
Article Title	Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients
Manuscript Source	Invited Manuscript
All Author List	Eman Ahmed Abd-Elmawgood, Mohammed H Hassan, Khaled Abdalla Abd-Elbaseer, Mona Hashem Ibrahem, Khaled Mohammed Hassan Yousef and Ali Helmi Bakri
Funding Agency and Grant Number
Corresponding Author	Mohammed H Hassan, MD, Professor, Department of Medical Biochemistry and Molecular Biology, Faculty of medicine, Qena University, Elsafwa School Street, Qena 83523, Egypt. mohammedhosnyhassaan@yahoo.com
Key Words	Growth differentiation factor 15 rs4808793; Pediatric cardiology; Single nucleotide polymorphism; Congenital heart diseases
Core Tip	Growth differentiation factor-15 (GDF-15) is increasingly recognized as a valuable biomarker and potential genetic contributor in pediatric cardiac disorders. Significantly elevated serum GDF-15 levels are observed in children with heart failure, reflecting disease severity and progression. Additionally, the higher prevalence of the C-allele of the GDF-15 rs4808793 polymorphism among patients with congenital heart disease supports a genetic susceptibility component. Together, these findings highlight the potential role of GDF-15 in development and progression of pediatric cardiovascular diseases.
Citation	Abd-Elmawgood EA, Hassan MH, Abd-Elbaseer KA, Ibrahem MH, Yousef KMH, Bakri AH. Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients. World J Clin Pediatr 2026; In press

Received	2025-12-04 00:41
Peer-Review Started	2025-12-04 00:41
First Decision by Editorial Office Director	2025-12-18 09:26
Return for Revision	2025-12-18 09:26
Revised	2025-12-22 20:56
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 07:13
Articles in Press	2026-02-03 07:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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