Publication Name	World Journal of Psychiatry
Manuscript ID	117289
DOI	10.5498/wjp.117289
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Observational Study
Article Title	Correlational study on plasma cytokine levels and severity of depression in first-episode adolescent depression patients
Manuscript Source	Unsolicited Manuscript
All Author List	Hao Dai, Jie Chen and Zhi-Peng Yin
Funding Agency and Grant Number	Funding Agency Grant Number Wenzhou Science and Technology Bureau No. Y20240648
Corresponding Author	Zhi-Peng Yin, Department of Emotional Disorders, Wenzhou Seventh People’s Hospital, Nanhui Sub-district, Wenzhou 325000, Zhejiang Province, China. daihaotqd2006@163.com
Key Words	Adolescents; Plasma cytokines; First-episode depression; Depression severity; Biomarkers
Core Tip	In this study, we investigated the relationship between plasma cytokine levels and severity of first-episode adolescent depression. A cross-sectional analysis of 100 patients and 50 controls revealed that levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha were significantly higher in severe cases than in mild-to-moderate cases before treatment. These differences normalized after 8 weeks of treatment. Logistic regression analysis identified IL-6 level as an independent risk factor. These findings suggest that these cytokines are dysregulated and are correlated with depression severity, indicating their potential use as biomarkers for diagnosis and clinical assessment.
Citation	Dai H, Chen J, Yin ZP. Correlational study on plasma cytokine levels and severity of depression in first-episode adolescent depression patients. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.117289
PDF	117289-in-press.pdf

Received	2026-01-20 09:55
Peer-Review Started	2026-01-20 09:55
First Decision by Editorial Office Director	2026-02-03 07:34
Return for Revision	2026-02-03 07:34
Revised	2026-02-27 04:09
Publication Fee Transferred
Second Decision by Editor	2026-07-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-29 09:31
Articles in Press	2026-07-29 09:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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