Publication Name	World Journal of Gastroenterology
Manuscript ID	117300
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Future directions in noninvasive prediction of cirrhosis decompensation: An opinion review
Manuscript Source	Unsolicited Manuscript
All Author List	Xin Gao, Dan-Yang Zhang and Yan Wang
Funding Agency and Grant Number	Funding Agency Grant Number the Shaanxi Provincial Key Research and Development Plan No. 2020SF-159
Corresponding Author	Yan Wang, Assistant Professor, MD, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 of Xiwu Road, Xi'an 710004, Shaanxi Province, China. sarrye@163.com
Key Words	Decompensated cirrhosis; Noninvasive prediction model; Spleen stiffness measurement; Hepatocellular carcinoma; Radiomics; Baveno VII criteria
Core Tip	The noninvasive model integrating liver stiffness and spleen stiffness has demonstrated high accuracy in predicting clinical decompensation in patients with viral cirrhosis. Future research should prioritize high-risk subgroups, particularly patients with hepatocellular carcinoma. Standardized protocols for spleen stiffness measurement must be established, and multistate models should be adopted to better characterize disease progression. Future models that combine clinical complexity with radiomics and artificial intelligence-enhanced surveillance may sharpen personalized risk assessment in decompensated cirrhosis.
Citation	Gao X, Zhang DY, Wang Y. Future directions in noninvasive prediction of cirrhosis decompensation: An opinion review. World J Gastroenterol 2026; In press

Received	2025-12-04 01:44
Peer-Review Started	2025-12-04 01:44
First Decision by Editorial Office Director	2026-02-06 10:42
Return for Revision	2026-02-06 10:42
Revised	2026-02-19 03:02
Publication Fee Transferred
Second Decision by Editor	2026-04-22 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-22 06:08
Articles in Press	2026-04-22 06:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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