Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117308
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing
Manuscript Source	Unsolicited Manuscript
All Author List	Sheng-Qiang Zhao, Zhao-Feng Luo, Zhan-Feng Yang, Wei-Shan Zhang and Yu-Ming Fu
Funding Agency and Grant Number	Funding Agency Grant Number Molecular Mechanism by the Henan Provincial Health and Wellness Committee No. SBGJ202102184
Corresponding Author	Yu-Ming Fu, MD, Department of Gastrointestinal and Thyroid Surgery, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qian Street, Erqi District, Zhengzhou 450052, Henan Province, China. yumingfu0204@126.com
Key Words	Colorectal cancer; Gene mutation; KRAS; TP53; Prognosis
Core Tip	This study used multi-gene next-generation sequencing in a resected colorectal cancer cohort to compare the clinicopathological and prognostic impact of KRAS, PIK3CA, FBXW7, and TP53 mutations. We found that KRAS mutation defines an aggressive phenotype and is an independent predictor of poor long-term survival, whereas PIK3CA, FBXW7, and TP53 mutations provide limited standalone prognostic information. These findings support routine KRAS genotyping for perioperative risk stratification and suggest that other recurrent mutations should be interpreted within integrated molecular models rather than in isolation.
Citation	Zhao SQ, Luo ZF, Yang ZF, Zhang WS, Fu YM. Independent prognostic value of KRAS mutation in resected colorectal cancer based on multi-gene sequencing. World J Gastrointest Oncol 2026; In press

Received	2025-12-04 01:52
Peer-Review Started	2025-12-04 01:52
First Decision by Editorial Office Director	2025-12-23 10:04
Return for Revision	2025-12-23 10:04
Revised	2025-12-24 13:48
Publication Fee Transferred	2025-12-29 01:58
Second Decision by Editor	2026-02-03 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 08:28
Articles in Press	2026-02-03 08:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com