Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117318
Country	China

Category	Food Science & Technology
Manuscript Type	Review
Article Title	Repairing the impaired gut vascular barrier as a novel therapeutic target for prolonged postoperative ileus: A scoping review
Manuscript Source	Unsolicited Manuscript
All Author List	Dan-Li Shen, Li Wan, Xiao-Chun Zhang, Yun-Da Fang, Hua-Chun Jiang, Yuan-Cheng Wei, Li-Feng Chen, Zhi-Ming Wu, Chen-Chen Ye, Chang Pei, Han Zhou and Li Qian
Funding Agency and Grant Number	Funding Agency Grant Number 2026 Annual Research Projects on Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine in Jiangsu Province CYTF2026056 Jiangsu Association of Chinese Medicine XYLD2024016
Corresponding Author	Li Qian, MD, Department of Preventive Treatment, Yixing Traditional Chinese Medicine Hospital, No. 128, Yangquan East Road, Wuxi 214200, Jiangsu Province, China. 18260026183@163.com
Key Words	Gut vascular barrier; Prolonged postoperative ileus; Intestinal microvascular endothelial cells; Therapeutic target; Vascular immunity
Core Tip	Prolonged postoperative ileus (PPOI) is a common iatrogenic complication following surgery, with an incidence rate ranging from 10% to 28%. Damage to the gut vascular barrier (GVB) and the subsequent vascular inflammatory response are key factors that contribute to the persistence of intestinal inflammation in PPOI. This review comprehensively examines the impact of intestinal microvascular endothelial cell dysfunction, increased GVB permeability, pathological angiogenesis, and alterations in intestinal microvascular hemodynamics on PPOI. It suggests that restoring the impaired GVB may present a promising therapeutic target for managing PPOI.
Citation	Shen DL, Wan L, Zhang XC, Fang YD, Jiang HC, Wei YC, Chen LF, Wu ZM, Ye CC, Pei C, Zhou H, Qian L. Repairing the impaired gut vascular barrier as a novel therapeutic target for prolonged postoperative ileus: A scoping review. World J Gastrointest Surg 2026; In press

Received	2025-12-10 01:23
Peer-Review Started	2025-12-10 05:34
First Decision by Editorial Office Director	2025-12-24 10:43
Return for Revision	2025-12-26 08:43
Revised	2026-01-20 06:29
Publication Fee Transferred	2026-01-21 13:07
Second Decision by Editor	2026-02-11 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 03:40
Articles in Press	2026-02-11 03:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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