Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117323
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Lin Cong, Si Tong, Yu-Jie Xu, De-Yu Zhang, Xiu-Mei Zhang and Hong Yu
Funding Agency and Grant Number	Funding Agency Grant Number Project Foundation of Taizhou School of Clinical Medicine, Nanjing Medical University No. TZKY20220205
Corresponding Author	Hong Yu, PhD, Department of Pathology, Taizhou People’s Hospital Affiliated to Dalin Medical University, No. 366 Taihu Road, Medical High-tech Zone, Taizhou 225300, Jiangsu Province, China. yuhong@njmu.edu.cn
Key Words	Metastasis-associated colon cancer 1; Pancreatic cancer; P53 pathway; Notch pathway; Multiomics; Tumor progression
Core Tip	Metastasis-associated colon cancer 1 (MACC1) is strongly upregulated in pancreatic cancer (PC) and shows consistent alterations across multiomics datasets. In this study, we combined pan-cancer bioinformatic profiling with functional experiments to clarify its role in PC. Silencing MACC1 suppressed proliferation, migration, invasion, and increased apoptosis, while overexpression produced the opposite effects. We also confirmed that MACC1 activates both p53 and Notch signaling. These findings show that MACC1 is not only a useful diagnostic and prognostic marker but also a potential therapeutic target in PC.
Citation	Cong L, Tong S, Xu YJ, Zhang DY, Zhang XM, Yu H. Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling. World J Gastrointest Oncol 2026; In press

Received	2025-12-08 03:34
Peer-Review Started	2025-12-08 03:34
First Decision by Editorial Office Director	2025-12-24 10:39
Return for Revision	2025-12-24 14:23
Revised	2025-12-29 12:00
Publication Fee Transferred	2026-01-02 10:09
Second Decision by Editor	2026-02-11 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 05:19
Articles in Press	2026-02-11 05:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com