Publication Name	World Journal of Gastroenterology
Manuscript ID	117348
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	From dinner table to liver: Allyl isothiocyanate aids metabolic dysfunction-associated steatotic liver disease treatment
Manuscript Source	Invited Manuscript
All Author List	Qing-Qing Zhou, Guang-Yu Yao and Teng-Fei Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82404058 Shanghai Municipal Commission of Health and Family Planning 2024ZZ2049 Beijing Xisike Clinical Oncology Research Foundation Y-HS202401-0011
Corresponding Author	Teng-Fei Liu, PhD, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No. 241 Huaihai West Road, Xuhui District, Shanghai 200030, China. liutfei@alumni.sjtu.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Allyl isothiocyanate; Vitamin D receptors; Treatment; Comment
Core Tip	Gao et al reveal a novel mechanism: Allyl isothiocyanate (AITC) alleviates metabolic dysfunction-associated steatotic liver disease by activating hepatic the vitamin D receptor to upregulate nuclear factor 4 alpha/microsomal triglyceride transfer protein/ApoB-mediated lipid export. This observation highlights the potential of AITC as a multi-target nutraceutical, though its clinical translation hinges on overcoming pharmacokinetic and phenotypic heterogeneity challenges.
Citation	Zhou QQ, Yao GY, Liu TF. From dinner table to liver: Allyl isothiocyanate aids metabolic dysfunction-associated steatotic liver disease treatment. World J Gastroenterol 2026; In press

Received	2025-12-05 00:33
Peer-Review Started	2025-12-05 08:39
First Decision by Editorial Office Director	2025-12-09 10:09
Return for Revision	2025-12-09 10:09
Revised	2025-12-23 01:22
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 12:06
Articles in Press	2026-02-09 12:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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