Publication Name	World Journal of Clinical Oncology
Manuscript ID	117365
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Diabetes mellitus and ovarian cancer: Intersecting pathways and clinical outcomes
Manuscript Source	Invited Manuscript
All Author List	Tirath Patel, Sara Kareem Ali, Yusur Jawad, Seba Hasan Haddad, Liyan Mahmoud Al Masri, Aya Rimawi, Reem Ahmed Alraeesi, Hessah Sultan Alkaabi, Muhammad Farhan, Maheen Zahid, Muhammad Ahmad, Neha Choudhary, Muhammad Hashir Nazir and Ayoola Awosika
Funding Agency and Grant Number
Corresponding Author	Ayoola Awosika, MD, Department of Family Medicine, University of Illinois College of Medicine Peoria, 1 Illini drive, Bloomington, IL 61601, United States. ayoolaawosika@yahoo.com
Key Words	Hyperinsulinemia; Insulin resistance; Inflammation; Metformin; Oxidative stress
Core Tip	Epidemiologic data consistently demonstrate that women with pre-existing diabetes mellitus have higher ovarian cancer incidence and poorer survival, yet the mechanistic underpinnings remain incompletely defined, and substantive knowledge gaps persist. Some biologic linkages uncovered include hyperglycemia, compensatory hyperinsulinemia, and chronic low-grade inflammation, creating a pro-tumorigenic milieu that enhances cellular proliferation, genomic instability, and metastatic potential. And at the molecular level, dysregulated insulin and insulin-like growth factor-1 signaling amplifies phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways, fostering anti-apoptotic signaling, metabolic reprogramming, and angiogenesis.
Citation	Patel T, Ali SK, Jawad Y, Haddad SH, Al Masri LM, Rimawi A, Alraeesi RA, Alkaabi HS, Farhan M, Zahid M, Ahmad M, Choudhary N, Nazir MH, Awosika A. Diabetes mellitus and ovarian cancer: Intersecting pathways and clinical outcomes. World J Clin Oncol 2026; In press

Received	2025-12-08 01:03
Peer-Review Started	2025-12-08 09:24
First Decision by Editorial Office Director	2025-12-16 09:15
Return for Revision	2025-12-16 09:15
Revised	2025-12-19 05:24
Publication Fee Transferred
Second Decision by Editor	2026-03-10 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-10 10:36
Articles in Press	2026-03-10 10:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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