Publication Name	World Journal of Hepatology
Manuscript ID	117367
Country	Colombia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Autoimmune liver diseases in older adults: Clinical challenges and management considerations
Manuscript Source	Invited Manuscript
All Author List	Pablo Guillermo Hernández-Almonacid, Juan Sebastian Espejo-Amado and Ximena Marín-Quintero
Funding Agency and Grant Number
Corresponding Author	Pablo Guillermo Hernández-Almonacid, Consultant, MD, Department of Internal Medicine, National University of Colombia, Kr 35 bis 60-45 A311, Bogota 111311, Colombia. pghernandezalm@gmail.com
Key Words	Autoimmune liver diseases; Autoimmune hepatitis; Primary biliary cholangitis; Primary sclerosing cholangitis; Aged; Geriatric comorbidities
Core Tip	Autoimmune liver diseases are increasingly relevant in older adults, with changing epidemiology and rising incidence, including presentation peaks in this age group. Clinical manifestations range from unusual presentations, acute liver failure, and acute hepatitis to more common indolent forms with minimal symptoms. Serologic testing does not differ from younger patients, but due to comorbidities, liver biopsy remains essential. First-line treatment generally does not change and is often effective, although older adults are more vulnerable to steroid-related complications and polypharmacy. Liver transplantation remains an option. However, this population is still understudied, and future research should incorporate comprehensive geriatric assessment
Citation	Hernández-Almonacid PG, Espejo-Amado JS, Marín-Quintero X. Autoimmune liver diseases in older adults: Clinical challenges and management considerations. World J Hepatol 2026; In press

Received	2025-12-08 00:42
Peer-Review Started	2025-12-08 00:42
First Decision by Editorial Office Director	2026-01-14 08:07
Return for Revision	2026-01-14 08:07
Revised	2026-01-27 04:03
Publication Fee Transferred
Second Decision by Editor	2026-02-13 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-13 08:03
Articles in Press	2026-02-13 08:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com