Publication Name	World Journal of Gastroenterology
Manuscript ID	117368
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	How serum uric acid-to-high-density lipoprotein cholesterol ratio predicts cardiovascular risk in metabolic dysfunction-associated steatotic liver disease: Addressing challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Juan Xu, Jing Ma, Shang Wei, Dan Hu and Yan-Qi Dang
Funding Agency and Grant Number	Funding Agency Grant Number the Digestive Diseases Committee of the Chinese Association of Traditional Chinese Medicine-The Youth Empowerment Program 202557-006 State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine LSLSKL20240127 Science and Technology Development Fund of Shanghai Pudong New Area PKJ2024-Y19 the Investigator-Initiated Trial Program of Shanghai Pudong New Area Health Commission (the Cohort Study Program) 2025-PWDL-03
Corresponding Author	Yan-Qi Dang, Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Fenglin Road Sub-district, Shanghai 200032, China. yq_dang@shutcm.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Cardiovascular risk; Serum uric acid-to-high-density lipoprotein cholesterol ratio; Emerging composite biomarker; Asian patients
Core Tip	This correspondence aims to contribute to the ongoing discourse on the utility of the uric acid to high-density lipoprotein cholesterol (UHR) as a predictive marker for cardiovascular disease risk in patients with metabolic dysfunction-associated steatotic liver disease, emphasizing critical considerations for its broader applicability. The primary focus of this letter is to underscore the potential of UHR as a cost-effective and integrative biomarker, while also addressing significant limitations such as single-center bias, medication-related confounders, and the necessity for more comprehensive demographic representation. Additionally, it seeks to actively promote future multicenter studies to validate these findings across diverse populations and settings.
Citation	Xu JJ, Ma J, Wei S, Hu D, Dang YQ. How serum uric acid-to-high-density lipoprotein cholesterol ratio predicts cardiovascular risk in metabolic dysfunction-associated steatotic liver disease: Addressing challenges. World J Gastroenterol 2026; In press

Received	2025-12-08 01:36
Peer-Review Started	2025-12-08 01:36
First Decision by Editorial Office Director	2026-01-08 09:29
Return for Revision	2026-01-08 09:29
Revised	2026-01-11 03:07
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 03:09
Articles in Press	2026-02-03 03:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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