Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	117377
Country	Egypt

Category	Pediatrics
Manuscript Type	Case Report
Article Title	Dilemma between knife and needle for acute abdomen in familial Mediterranean fever: Two case reports and review of literature
Manuscript Source	Invited Manuscript
All Author List	Ahmed M Sira, Samar A Shoeir and Mostafa M Sira
Funding Agency and Grant Number
Corresponding Author	Mostafa M Sira, MD, Professor, Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Gamal Abdel Nasser Street, Shebin El-Koom 32511, Menoufia, Egypt. msira@liver.menofia.edu.eg
Key Words	Abdominal ultrasonography; Acute abdomen; Acute appendicitis; Alvarado score; Familial Mediterranean fever; Peritonitis; Non-operative management; Case report
Core Tip	Children with familial Mediterranean fever (FMF) may present with acute abdominal attacks that resemble acute appendicitis. Diagnostic discrimination is challenging due to the mimicry in clinical, laboratory, and even some radiological findings. We presented two children with acute abdomen: One was managed surgically despite the absence of radiological evidence of appendicitis. In contrast, the other was managed conservatively despite radiological findings of a slightly inflamed appendix. Both were ultimately diagnosed with FMF. This highlights the importance of differentiating the causes of acute abdomen by maintaining a high index of suspicion for FMF, particularly in endemic areas of the Mediterranean basin.
Citation	Sira AM, Shoeir SA, Sira MM. Dilemma between knife and needle for acute abdomen in familial Mediterranean fever: Two case reports and review of literature. World J Clin Pediatr 2026; In press

Received	2025-12-08 01:14
Peer-Review Started	2025-12-08 01:14
First Decision by Editorial Office Director	2025-12-24 09:44
Return for Revision	2025-12-24 09:44
Revised	2026-01-07 06:04
Publication Fee Transferred
Second Decision by Editor	2026-01-22 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-22 05:35
Articles in Press	2026-01-22 05:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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