Publication Name	World Journal of Hepatology
Manuscript ID	117382
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Natural product intervention in metabolic dysfunction-associated steatotic liver disease: From allyl isothiocyanate to signaling networks
Manuscript Source	Invited Manuscript
All Author List	Rui Tian, Yi-Xin Wu, Jie-Yu Guo, Xing-Zhen Chen, Jing-Feng Tang and Ce-Fan Zhou
Funding Agency and Grant Number
Corresponding Author	Ce-Fan Zhou, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Key Words	Allyl isothiocyanate; Metabolically-dysfunction-associated steatotic liver disease; Vitamin D receptor; Multitarget therapy; Network pharmacology
Core Tip	This comment highlights that allyl isothiocyanate (AITC) illustrates the principle of multi-target natural product therapy for metabolic dysfunction-associated steatotic liver disease. Beyond the novel vitamin D receptor/hepatocyte nuclear factor 4 alpha pathway identified by Gao et al, we integrate this axis with established AITC targets, such as sirtuin 1/AMP-activated protein kinase, nuclear factor erythroid 2-related factor 2, to construct a multiple-signaling network. This network collectively reprograms lipid metabolism, insulin sensitivity, and oxidative stress. Future research must validate this integrative mechanism in vivo and leverage systems biology to advance AITC as a precise, network-based therapeutic strategy.
Citation	Tian R, Wu YX, Guo JY, Chen XZ, Tang JF, Zhou CF. Natural product intervention in metabolic dysfunction-associated steatotic liver disease: From allyl isothiocyanate to signaling networks. World J Hepatol 2026; In press

Received	2025-12-08 00:49
Peer-Review Started	2025-12-08 00:49
First Decision by Editorial Office Director	2025-12-16 10:06
Return for Revision	2025-12-17 09:27
Revised	2025-12-25 09:57
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 09:54
Articles in Press	2026-02-05 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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