Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	117397
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Helicobacter pylori positively associated with colorectal cancer and advanced, but not low-risk, adenomas: A retrospective study in China
Manuscript Source	Unsolicited Manuscript
All Author List	Na Shan, Jun-Jie Hou, Chao-Qiong Jin, Qi Jin, Yue-Hua Qin and Wei-Wei Li
Funding Agency and Grant Number	Funding Agency Grant Number the Shaoxing City Health Science and Technology Plan Project Foundation of China 2023SKY025
Corresponding Author	Wei-Wei Li, Associate Chief Physician, Department of Gastroenterology, Shaoxing People’s Hospital, The First Affiliated Hospital of Shaoxing University, No. 568 Zhongxing North Road, Yuecheng District, Shaoxing 312000, Zhejiang Province, China. rmyy02672@usx.edu.cn
Key Words	Helicobacter pylori; Colorectal advanced adenomas; Colorectal cancer; Retrospective cross-sectional study; Multivariable logistic regression analysis
Core Tip	In the Chinese population, it remains unclear whether Helicobacter pylori (H. pylori) infection is involved in the early stages of colorectal carcinogenesis or is associated with the risk of colorectal polyps. We conducted a retrospective study based on 5986 gastroscopy and colonoscopy patients without a treatment history of H. pylori in Zhejiang Province (China). We found that H. pylori infection was a risk factor for both advanced adenomas and colorectal cancer in a similar clinical population of Chinese, but not non-adenomatous polyps or low-risk adenomas. Therefore, H. pylori-positive patients should undergo colonoscopy.
Citation	Shan N, Hou JJ, Jin CQ, Jin Q, Qin YH, Li WW. Helicobacter pylori positively associated with colorectal cancer and advanced, but not low-risk, adenomas: A retrospective study in China. World J Gastrointest Surg 2026; In press

Received	2025-12-08 02:15
Peer-Review Started	2025-12-08 02:15
First Decision by Editorial Office Director	2025-12-16 06:30
Return for Revision	2025-12-16 06:30
Revised	2025-12-25 16:11
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 05:15
Articles in Press	2026-02-05 05:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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