Publication Name	World Journal of Stem Cells
Manuscript ID	117414
Country	China

Category	Hematology
Manuscript Type	Letter to the Editor
Article Title	Selection of adipose tissue sources for mesenchymal stem cell isolation: Phenotypic uniformity accompanied by secretome variability
Manuscript Source	Invited Manuscript
All Author List	Qing Xu, Nan Zhang and Jian-Chuan Deng
Funding Agency and Grant Number
Corresponding Author	Jian-Chuan Deng, Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan’an District, Chongqing 400010, China. dengjccq@hospital.cqmu.edu.cn
Key Words	Solid adipose tissue; Liposuction aspirates; Secretome variability; Clinical translation; Adipose-derived mesenchymal stem cells
Core Tip	This commentary highlights the first systematic comparison of adipose-derived mesenchymal stem cells obtained from solid adipose tissue and liposuction aspirates, emphasizing their phenotypic uniformity yet distinct secretome profiles. Beyond summarizing the original findings, it outlines four critical research directions overlooked in prior work: Functional implications of source-specific secretome factors (fibroblast growth factor 2 vs keratinocyte growth factor), cellular heterogeneity revealed by single-cell analyses, stemness preservation during extended passaging, and challenges in clinical translation and quality control. These insights provide a conceptual framework for optimizing manufacturing and advancing large-scale therapeutic application of the cells.
Citation	Xu Q, Zhang N, Deng JC. Selection of adipose tissue sources for mesenchymal stem cell isolation: Phenotypic uniformity accompanied by secretome variability. World J Stem Cells 2026; In press

Received	2025-12-08 02:34
Peer-Review Started	2025-12-08 02:34
First Decision by Editorial Office Director	2026-01-14 08:33
Return for Revision	2026-01-14 08:33
Revised	2026-01-25 06:15
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 08:11
Articles in Press	2026-02-25 08:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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