Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	117421
Country	Egypt

Category	Pediatrics
Manuscript Type	Review
Article Title	From genes to environment: A life-course approach to prevent pediatric autoimmune diseases
Manuscript Source	Invited Manuscript
All Author List	Mohammed Al-Beltagi, Nermin K Saeed, Adel S Bediwy, Eman A Bediwy and Reem Elbeltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Chairman, Consultant, Full Professor, MD, PhD, Senior Researcher, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mohamed.elbeltagi@med.tanta.edu.eg
Key Words	Pediatric autoimmunity; Children; Precision prevention; Microbiome; Teplizumab; Immunomodulation; Primary prevention; Exposome
Core Tip	The rising global incidence of pediatric autoimmune diseases necessitates a strategic shift from reactive disease management to proactive prevention. This article outlines a comprehensive, integrated framework that leverages advances in genomics and exposomics to identify and intervene in high-risk children. The model begins with primordial prevention during the first 1000 days, progressing through primary and secondary interventions, and concluding with aggressive therapy for established disease. By adopting this tiered approach, clinicians, researchers, and public health officials can work collaboratively to alter disease trajectories, reduce the long-term burden of these conditions, and ultimately improve the health outcomes for future generations.
Citation	Al-Biltagi M, Saeed NK, Bediwy AS, Bediwy EA, Elbeltagi R. From genes to environment: A life-course approach to prevent pediatric autoimmune diseases. World J Clin Pediatr 2026; In press

Received	2025-12-08 02:49
Peer-Review Started	2025-12-08 02:50
First Decision by Editorial Office Director	2025-12-24 09:44
Return for Revision	2025-12-24 09:44
Revised	2025-12-24 17:40
Publication Fee Transferred
Second Decision by Editor	2026-03-17 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 04:23
Articles in Press	2026-03-17 04:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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