Publication Name	World Journal of Clinical Cases
Manuscript ID	117431
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Combined anticoagulant deficiency causing extrahepatic portal venous obstruction: A case report
Manuscript Source	Invited Manuscript
All Author List	Arkadeep Dhali, Rick Maity, Arijit Sinha, Prithviraj Singh, Jyotirmoy Biswas and Gopal Krishna Dhali
Funding Agency and Grant Number
Corresponding Author	Rick Maity, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Ardeshir Dalal Avenue, Kharagpur 721302, India. rickmaity98@gmail.com
Key Words	Extrahepatic portal venous obstruction; Portal vein; Portal vein thrombosis; Protein S deficiency; Protein C deficiency; Antithrombin III deficiency; Case Report
Core Tip	Extrahepatic portal venous obstruction (EHPVO) is a leading cause of non-cirrhotic portal hypertension in young individuals. It is linked to procoagulable states; however, combined anticoagulant deficiencies are rare. This case describes a 27-year-old adult with long-standing EHPVO complicated by recurrent thrombotic and hemorrhagic events in the setting of combined deficiencies of protein S, protein C, and antithrombin III. It highlights the diagnostic uncertainty in distinguishing between acquired and inherited anticoagulant deficiencies in chronic portal vein thrombosis and underscores the clinical challenge of balancing anticoagulation against the risk of bleeding in EHPVO.
Citation	Dhali A, Maity R, Sinha A, Singh P, Biswas J, Dhali GK. Combined anticoagulant deficiency causing extrahepatic portal venous obstruction: A case report. World J Clin Cases 2026; In press

Received	2025-12-08 02:53
Peer-Review Started	2025-12-08 02:53
First Decision by Editorial Office Director	2025-12-31 07:52
Return for Revision	2025-12-31 07:52
Revised	2026-01-13 20:57
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 09:48
Articles in Press	2026-02-02 09:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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