Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117434
Country	China

Category	Chemistry, Organic
Manuscript Type	Opinion Review
Article Title	From association to intervention: Rethinking CD24’s causal role in hepatocellular carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Li-Na Ren, Cong Liu, Cheng-Qiang Jin and Xiang-Hui Zhang
Funding Agency and Grant Number
Corresponding Author	Cheng-Qiang Jin, Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, No. 89 Guhuai Road, Jining 272029, Shandong Province, China. jincq2008@163.com
Key Words	CD24; Hepatocellular carcinoma; Programmed death-ligand 1; Immune evasion; Biomarker; Clustered regularly interspaced short palindromic repeats; Single-cell RNA sequencing; Spatial transcriptomics
Core Tip	A recent study report dynamic up-regulation of CD24 during hepatocarcinogenesis, improving alpha-fetoprotein -negative hepatocellular carcinoma detection. However, this study lacks functional validation, subset resolution, and mechanistic linkage to programmed death-ligand 1. Functional genetics, single-cell, multi-omics, and spatial analyses are needed to confirm CD24’s causality and therapeutic potential.
Citation	Ren LN, Liu C, Jin CQ, Zhang XH. From association to intervention: Rethinking CD24’s causal role in hepatocellular carcinogenesis. World J Gastrointest Oncol 2026; In press

Received	2025-12-08 02:43
Peer-Review Started	2025-12-08 02:44
First Decision by Editorial Office Director	2026-01-08 09:30
Return for Revision	2026-01-08 12:56
Revised	2026-02-12 12:39
Publication Fee Transferred
Second Decision by Editor	2026-04-01 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-01 12:02
Articles in Press	2026-04-01 12:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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