Publication Name	World Journal of Hepatology
Manuscript ID	117441
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging
Manuscript Source	Unsolicited Manuscript
All Author List	Amany Sholkamy, Ahmed El-Meligui, Eman H Saad, Samar Amin, Mirette Makram, Noha Elmansy and Shrook Mousa
Funding Agency and Grant Number
Corresponding Author	Mirette Makram, Consultant, MD, Department of Endocrinology Section, Department of Internal Medicine, Kasralainy Hospitals, Cairo University, 1 Gamaa Street, Giza, Cairo 12613, Al Qāhirah, Egypt. mirettemakram@kasralainy.edu.eg
Key Words	Metabolic dysfunction-associated steatotic liver disease; Hypothyroidism; Overt; Subclinical; Predictors; Fibrosis; Severity; Ultrasonography; Magnetic resonance imaging
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the foremost etiology of cirrhosis and hepatocellular carcinoma. Our study assessed the overlooked association between this global liver disease and the spectrum of hypothyroidism. The three study groups (overt, subclinical hypothyroid, control) were assessed for MASLD by ultrasonography. The diagnosis was confirmed by magnetic resonance imaging, hepatic fat percentage was calculated. Ultrasound results were compared with magnetic resonance imaging findings to determine degree of agreement between both diagnostic methods. Multivariate analysis identified the independent risk variables associated with the onset and severeness of MASLD. The receiver operating characteristic curve concluded that there is a certain thyroid-stimulating hormone level above which the risk of MASLD development increases.
Citation	Sholkamy A, El-Meligui A, Saad EH, Amin S, Makram M, Elmansy N, Mousa S. Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging. World J Hepatol 2026; In press

Received	2025-12-08 03:46
Peer-Review Started	2025-12-08 03:46
First Decision by Editorial Office Director	2025-12-25 08:24
Return for Revision	2025-12-25 08:24
Revised	2026-01-07 13:08
Publication Fee Transferred	2026-01-09 16:19
Second Decision by Editor	2026-02-11 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-11 09:38
Articles in Press	2026-02-11 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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