Publication Name	World Journal of Experimental Medicine
Manuscript ID	117464
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Cohort Study
Article Title	Diabetic ketoacidosis in patients with type 2 diabetes: Risk factors for mortality and adverse outcomes
Manuscript Source	Invited Manuscript
All Author List	Vishnu Chandrabalan, Timothy Howcroft, Mohammed Khalid Alkhalifah, Noorulanne Younis, Ebrahim Aldhafiri and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, MRCP, Professor, Senior Researcher, Faculty of Science,, Manchester Metropolitan University, Manchester, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Type 2 diabetes mellitus; Diabetic ketoacidosis; Dementia; Peripheral vascular disease; Heart failure; Mortality risk
Core Tip	Diabetic ketoacidosis (DKA) resulting from type 2 diabetes mellitus (T2DM) is less common. A retrospective analysis of 464 patients from a tertiary-care United Kingdom hospital with DKA and T2DM identified that mortality rates at 30 and 90 days were 13.4% and 11% respectively after the index DKA event. The survival after the DKA event was only 58.6% on long-term follow-up. Coexistent peripheral vascular disease, congestive heart failure, and lower estimated glomerular filtration rate were the important predictors of inpatient mortality. Factors associated with long-term mortality risk were dementia, and older age at presentation and continued use of older antidiabetic agents like sulfonylurea/metformin.
Citation	Chandrabalan V, Howcroft T, Alkhalifah MK, Younis N, Aldhafiri E, Pappachan JM. Diabetic ketoacidosis in patients with type 2 diabetes: Risk factors for mortality and adverse outcomes. World J Exp Med 2026; In press

Received	2025-12-24 03:23
Peer-Review Started	2025-12-24 03:24
First Decision by Editorial Office Director	2026-01-07 02:31
Return for Revision	2026-01-07 02:31
Revised	2026-01-11 21:41
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 08:21
Articles in Press	2026-02-05 08:21
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Typeset the Manuscript

ISSN	2220-315x (online)
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