Publication Name	World Journal of Diabetes
Manuscript ID	117497
Country	China

Category	Cell Biology
Manuscript Type	Editorial
Article Title	Endothelial cell-derived exosomes: A natural shield against osteoblast ferroptosis in diabetes
Manuscript Source	Invited Manuscript
All Author List	Xiao-Cheng Zhong and Xia Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82570522
Corresponding Author	Xia Wang, Associate Professor, Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University School of Medicine, No. 241 Huaihai West Road, Xuhui District, Shanghai 200030, China. wangxia31610@163.com
Key Words	Diabetic osteoporosis; Endothelial cell-derived exosomes; Ferroptosis Prostaglandin endoperoxide synthase 2; microRNA-335-3p; Bone mineral density
Core Tip	Diabetic osteoporosis (DOP), a common diabetic complication lacking targeted treatments, stems from chronic hyperglycemia disrupting the bone microenvironment. Key pathophysiological mechanisms include the accumulation of advanced glycation end products, oxidative stress, inflammation, and cell death. Currently, the field of DOP is moving beyond bone mineral density to understand the molecular and cellular dysregulation at the bone-vascular interface, aiming for precise diagnostics and therapies. This editorial highlight endothelial cell-derived exosomes and their cargo microRNA-335-3p as emerging and critical players in the pathophysiology of DOP. It discusses their role in inhibiting osteoclast ferroptosis and alleviating bone loss, while also identifying serum microRNA-335-3p as a promising non-invasive biomarker for early detection and monitoring, bridging molecular mechanisms with clinical translation.
Citation	Zhong XC, Wang X. Endothelial cell-derived exosomes: A natural shield against osteoblast ferroptosis in diabetes. World J Diabetes 2026; In press

Received	2025-12-10 00:29
Peer-Review Started	2025-12-11 00:16
First Decision by Editorial Office Director	2025-12-19 08:10
Return for Revision	2025-12-19 08:10
Revised	2025-12-25 09:39
Publication Fee Transferred
Second Decision by Editor	2026-01-12 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 08:47
Articles in Press	2026-01-12 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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