Publication Name	World Journal of Gastroenterology
Manuscript ID	117508
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Origin recognition complex subunit 1 as a biomarker in hepatitis B virus-related hepatocellular carcinoma: Promises and pitfalls
Manuscript Source	Unsolicited Manuscript
All Author List	Lian-Bang Wang, Xi-Ming Wang, Xin-Ya Zhao and Gong-Zheng Wang
Funding Agency and Grant Number
Corresponding Author	Gong-Zheng Wang, MD, PhD, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. wanggz0322@163.com
Key Words	Hepatocellular carcinoma; Hepatitis B virus; Origin recognition complex subunit 1; Diagnostic biomarker; Alpha-fetoprotein-negative
Core Tip	Serum origin recognition complex subunit 1 has emerged as a potential biomarker for hepatitis B virus-related hepatocellular carcinoma, which improved diagnostic accuracy when combined with extra spindle pole bodies-like 1 and alpha-fetoprotein. These indicators may eventually be integrated into a unified surveillance model to enhance early detection. Large, multicenter prospective studies and standardized assay development are essential to confirm its applicability across diverse clinical settings.
Citation	Wang LB, Wang XM, Zhao XY, Wang GZ. Origin recognition complex subunit 1 as a biomarker in hepatitis B virus-related hepatocellular carcinoma: Promises and pitfalls. World J Gastroenterol 2026; In press

Received	2025-12-09 03:59
Peer-Review Started	2025-12-09 03:59
First Decision by Editorial Office Director	2025-12-24 10:42
Return for Revision	2025-12-24 10:42
Revised	2026-01-06 12:59
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 05:28
Articles in Press	2026-02-03 05:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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