Publication Name	World Journal of Diabetes
Manuscript ID	117524
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Shenqi Jiangtang Granules attenuate ferroptosis in diabetic cardiomyopathy via the dihydroorotate dehydrogenase-coenzyme Q pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Ting Tang, Yu-Peng Chen, Ya-Nan Yang, Jun-Li Liu, Qian Wu, Shan Zhang, Qing Pang, Mao-Ying Wei, Yan-Bing Gong and Qing Ni
Funding Agency and Grant Number	Funding Agency Grant Number the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation GZC20230324 China Postdoctoral Science Foundation 2024M750263 the Leading Talent Training Program Project of Dongzhimen Hospital, Beijing University of Chinese Medicine DZMG-LJRC0004 the Fundamental Research Funds for the Central Universities 2023-JYB-JBZD-010 the High-Level Chinese Medical Hospital Promotion Project HLCMHPP2023084 the National Key R&D Program of China 2024ZD0523503
Corresponding Author	Qing Ni, Professor, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange, Xicheng District, Beijing 100053, China. niqing2834@gamyy.cn
Key Words	Shenqi Jiangtang Granules; Diabetic cardiomyopathy; Ferroptosis; DHODH/CoQ pathway; Oxidative stress
Core Tip	This study investigates the mechanisms of Shenqi Jiangtang Granules (SQJT) against diabetic cardiomyopathy (DCM). By integrating network pharmacology and experimental validation, we identified dihydroorotate dehydrogenase (DHODH) as a key therapeutic target. We demonstrate that SQJT mitigates ferroptosis and mitochondrial injury in H9C2 cardiomyocytes by activating the DHODH/coenzyme Q axis. These protective effects are significantly abolished by DHODH inhibition. This research provides mechanistic evidence that SQJT exerts cardioprotective effects through ferroptosis regulation, and highlights its potential as a therapeutic strategy for mitochondrial dysfunction in DCM.
Citation	Tang YT, Chen YP, Yang YN, Liu JL, Wu Q, Zhang S, Pang Q, Wei MY, Gong YB, Ni Q. Shenqi Jiangtang Granules attenuate ferroptosis in diabetic cardiomyopathy via the dihydroorotate dehydrogenase-coenzyme Q pathway. World J Diabetes 2026; In press

Received	2025-12-12 00:12
Peer-Review Started	2025-12-14 15:20
First Decision by Editorial Office Director	2026-02-03 08:26
Return for Revision	2026-02-03 08:26
Revised	2026-02-16 07:36
Publication Fee Transferred	2026-02-22 07:04
Second Decision by Editor	2026-04-08 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-08 06:54
Articles in Press	2026-04-08 06:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com