Publication Name	World Journal of Stem Cells
Manuscript ID	117525
Country	China

Category	Andrology
Manuscript Type	Letter to the Editor
Article Title	Extracellular vesicles in diabetic bladder dysfunction: A promising cell-free therapeutic avenue from amniotic fluid stem cells
Manuscript Source	Invited Manuscript
All Author List	Zhuo-Yin Liang and Hai-Sheng Hu
Funding Agency and Grant Number
Corresponding Author	Zhuo-Yin Liang, MD, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, No. 151 Yanjiang West Road, Guangzhou 510120, Guangdong Province, China. emeyou@163.com
Key Words	Extracellular vesicles; Diabetic bladder dysfunction; Amniotic fluid stem cells; Regenerative therapy; Urology
Core Tip	This letter examines the transformative potential of stem cell-derived extracellular vesicles as a novel cell-free regenerative strategy for diabetic bladder dysfunction. This underscores their unique capacity to simultaneously modulate urodynamic function, systemic metabolism, and local inflammatory-fibrotic pathways, thereby addressing the multifactorial pathogenesis of the condition. Representing a shift from symptomatic management to disease modification, extracellular vesicles offer a favorable safety profile and enhanced translational feasibility compared with whole-cell therapies. This discussion further outlines the critical steps for clinical integration, including cargo optimization, manufacturing standardization, and combination with postoperative rehabilitation.
Citation	Liang ZY, Hu HS. Extracellular vesicles in diabetic bladder dysfunction: A promising cell-free therapeutic avenue from amniotic fluid stem cells. World J Stem Cells 2026; In press

Received	2025-12-10 00:27
Peer-Review Started	2025-12-10 00:27
First Decision by Editorial Office Director	2026-01-12 08:32
Return for Revision	2026-01-12 08:32
Revised	2026-01-16 09:09
Publication Fee Transferred
Second Decision by Editor	2026-02-11 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 09:05
Articles in Press	2026-02-12 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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